Sugar–Protein Connectivity Impacts on the Immunogenicity of Site-Selective Salmonella O-Antigen Glycoconjugate Vaccines
نویسندگان
چکیده
Glycoproteins In their Communication on page 13198 ff., Q.-Y. Hu, F. Micoli et al. present two methods for the preparation of glycoconjugate vaccines with one single sugar chain linked to one or two positions of a carrier protein.
منابع مشابه
Strain Selection for Generation of O-Antigen-Based Glycoconjugate Vaccines against Invasive Nontyphoidal Salmonella Disease
Nontyphoidal Salmonellae, principally S. Typhimurium and S. Enteritidis, are a major cause of invasive bloodstream infections in sub-Saharan Africa with no vaccine currently available. Conjugation of lipopolysaccharide O-antigen to a carrier protein constitutes a promising vaccination strategy. Here we describe a rational process to select the most appropriate isolates of Salmonella as source o...
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